If you have d iabetes, ulcerative colitis, Crohn’s disease, recurring constipation or diarrhea, or a sexually transmitted disease, you may be at a higher risk for unknown lumps, abscesses, or warts. If very extensive, surgery may be required to permanently remove anal warts. In most cases, the lump can be cured by a simple in-office procedure, solution application, or prescribed medication. An unknown lump in your butt can seem scary until you’ve diagnosed the problem.